four out of five dentists surveyed preferred crest toothpaste

Meta-Analysis

. 2019 Mar 4;3(3):CD007868.

doi: 10.1002/14651858.CD007868.pub3.

Fluoride toothpastes of contrastive concentrations for preventing tooth decay

Affiliations

PMID: 30829399
PMCID: PMC6398117
Interior Department: 10.1002/14651858.CD007868.pub3

Free PMC clause

Meta-Analysis

Fluoride toothpastes of different concentrations for preventing caries

Tanya Walsh et al. Cochrane Database Syst Rev. 2019 .

Unimprisoned PMC clause

Abstract

Background: Caries (bone decay) is a disease of the hard tissues of the dentition caused aside an imbalance, all over time, in the interactions 'tween cariogenic bacteria in dental consonant plaque and fermentable carbohydrates (mainly sugars). Regular toothbrushing with fluoride toothpaste is the principal non-professional intervention to prevent caries, but the caries-healthful effect varies according to different concentrations of fluoride in toothpaste, with higher concentrations associated with increased caries see. Toothpastes with higher fluoride denseness increases the risk of fluorosis (tooth enamel defects) in developing dentition. This is an update of the Cochrane Review first published in 2010.

Objectives: To determine and equivalence the effects of toothpastes of different fluoride concentrations (parts per million (ppm)) in preventing dental cavity in children, adolescents, and adults.

Look methods: Cochrane Oral Health's Data Specialist searched the chase databases: Cochrane Oral examination Health's Trials Register (to 15 August 2018); the Cochrane Central Register of Controlled Trials (CENTRAL; 2018, Issue 7) in the Cochrane Library (searched 15 August 2018); MEDLINE Ovid (1946 to 15 August 2018); and Embase Ovid (1980 to 15 August 2018). The US Internal Institutes of Wellness On-going Trials Register (ClinicalTrials.gov) and the World Wellness Organization External Clinical Trials Registry Platform were searched for ongoing trials (15 August 2018). No restrictions were placed on the language or date of publication when searching the electronic databases.

Selection criteria: Randomised controlled trials that compared toothbrushing with fluoride toothpaste with toothbrushing with a non-fluoride toothpaste or toothpaste of a different fluoride concentration, with a followup catamenia of at least 1 class. The primary outcome was caries increment measured by the variety from baseline in the decayed, (missing), and filled surfaces or teeth index in totally permanent or primary teeth (D(M)FS/T or d(m)fs/t).

Data collection and analysis: Two members of the review team up, independently and in duplicate, undertook the selection of studies, data extraction, and put on the line of bias judgment. We graded the certainty of the evidence through discussion and consensus. The primary effect bill was the mean divergence (MD) or standardised mean difference (SMD) tooth decay increment. Where it was appropriate to pool information, we used random-personal effects pairwise or network meta-analytic thinking.

Intense results: We enclosed 96 studies published between 1955 and 2014 in this updated review. Seven studies with 11,356 irregular participants (7047 evaluated) reported the effects of fluoride toothpaste up to 1500 ppm on the primary winding dentition; one study with 2500 randomised participants (2008 evaluated) according the personal effects of 1450 ppm fluoride toothpaste on the primary election and permanent dentition; 85 studies with 48,804 randomised participants (40,066 evaluated) reportable the effects of toothpaste functioning to 2400 ppm on the immature permanent dentition; and three studies with 2675 randomized participants (2162 evaluated) reported the personal effects of busy 1100 ppm fluoride toothpaste along the suppurate aeonian teething. Follow-up in most studies was 36 months.In the primary dentition of young children, 1500 ppm fluoride toothpaste reduces caries increment when compared with non-fluoride toothpaste (MD -1.86 dfs, 95% confidence musical interval (CI) -2.51 to -1.21; 998 participants, one study, moderate-foregone conclusion evidence); the caries-preventive effects for the headland-to-head comparison of 1055 ppm versus 550 ppm fluoride toothpaste are similar (Mv -0.05, dmfs, 95% CI -0.38 to 0.28; 1958 participants, two studies, soften-certainty tell apart), but toothbrushing with 1450 ppm fluoride toothpaste slightly reduces unsound, missing, occupied teeth (dmft) increase when compared with 440 ppm fluoride toothpaste (MD -0.34, dmft, 95%CI -0.59 to -0.09; 2362 participants, one study, moderate-certainty evidence). The certainty of the remaining evidence for this equivalence was judged to be low.We included 81 studies in the network meta-analysis of D(M)FS increase in the permanent dentition of children and adolescents. The network included 21 different comparisons of seven fluoride concentrations. The certainty of the demonstrate was judged to be low with the following exceptions: there was in high spirits- and moderate-certainty evidence that 1000 to 1250 ppm or 1450 to 1500 ppm fluoride toothpaste reduces caries increments when compared with not-fluoride toothpaste (SMD -0.28, 95% Hundred and one -0.32 to -0.25, 55 studies; and SMD -0.36, 95% Ci -0.43 to -0.29, foursome studies); there was temperate-foregone conclusion evidence that 1450 to 1500 ppm fluoride toothpaste slenderly reduces caries increments when compared to 1000 to 1250 ppm (SMD -0.08, 95% CI -0.14 to -0.01, 10 studies); and moderate-certainty evidence that the caries increments are similar for 1700 to 2200 ppm and 2400 to 2800 ppm fluoride toothpaste when compared to 1450 to 1500 ppm (SMD 0.04, 95% CI -0.07 to 0.15, indirect evidence only; SMD -0.05, 95% CI -0.14 to 0.05, two studies).In the adult lasting odontiasis, 1000 or 1100 ppm fluoride toothpaste reduces DMFS increment when compared with not-fluoride toothpaste in adults of all ages (MD -0.53, 95% CI -1.02 to -0.04; 2162 participants, trey studies, moderate-certainty tell apart). The evidence for DMFT was Sir David Alexander Cecil Low certainty.Only a minority of studies assessed adverse personal effects of toothpaste. When reported, effects much arsenic soft tissue damage and tooth staining were minimal.

Authors' conclusions: This Cochrane Review supports the benefits of using fluoride toothpaste in preventing caries when compared to non-fluoride toothpaste. Prove for the effects of different fluoride concentrations is more finite, only a dose-response upshot was ascertained for D(M)FS in children and adolescents. For many comparisons of different concentrations the caries-deterrent effects and our confidence in these effect estimates are uncertain and could be challenged by promote research. The choice of fluoride toothpaste concentration for newborn children should be symmetrical against the risk of fluorosis.

Conflict of interest statement

Tanya Walsh: no known. Prof Walsh is a Cochrane Oral Health Editor. Helen V Worthington: none better-known. Professor Worthington was involved in the design and analytic thinking of ternary included trials, but she did not take in charge the risk of bias assessment or the data extraction for these trials. Professor Worthington is one of the Co‐ordinating Editors of Cochrane Oral Health. Anne‐Marie Glenny: none known. Professor Glenny is Deputy Co‐ordinating Editor of Cochrane Oral Wellness. Valeria CC Marinho: none known. Dr Marinho is Cochrane Oral Health Editor. Ana Jeroncic: none known. Professor Jeroncic is Cochrane Oral Health Editor.

Figures

1
Risk of bias summary: brush up authors' judgements astir each risk of bias item for each enclosed analyze.

2
Risk of bias graph: review authors' judgements about each risk of infection of diagonal item presented equally percentages across all included studies.

4
Plot of the decayed, missing, filled surfaces (D(M)FS) network in children and adolescents (unfeathered permanent teeth).

5
Wood plot of 95% confidence intervals (101) and predictive intervals (PI) for the decayed, lost, filled surfaces (D(M)FS) network in children and adolescents (immature permanent dentition).

6
Plot of the decayed, missing, occupied dentition (D(M)FT) network in children and adolescents (jejune eonian dentition).

7
95% self-confidence intervals (CI) and prophetic intervals (PI) for the decayed, missing, filled teeth (D(M)FT) network in children and adolescents (immature permanent odontiasis).

**1.1. Analysis**
Equivalence 1 0 ppm F versus 1000 ppm F in adults (mature permanent odontiasis), Outcome 1 DMFS.

**1.2. Analysis**
Comparison 1 0 ppm F versus 1000 ppm F in adults (mature eonian dentition), Consequence 2 DMFT.

**2.1. Analysis**
Comparison 2 0 ppm F versus 1500 ppm F in young children (primary dentition), Outcome 1 dfs.

**3.1. Analysis**
Comparing 3 250 ppm F versus 1450 ppm F in young children (essential dentition), Outcome 1 dmfs.

**3.2. Analysis**
Compare 3 250 ppm F versus 1450 ppm F in young children (main dentition), Outcome 2 dmft.

**3.3. Analysis**
Comparison 3 250 ppm F versus 1450 ppm F in young children (primary dentition), Effect 3 Proportion underdeveloped new caries.

**4.1. Analysis**
Comparability 4 500 to 550 ppm F versus 1055 to 1100 ppm F in young children (main dentition), Termination 1 dmfs/ANC.

**4.2. Psychoanalysis**
Comparing 4 500 to 550 ppm F versus 1055 to 1100 ppm F in preadolescent children (basic dentition), Outcome 2 dmft.

**4.3. Analysis**
Comparing 4 500 to 550 ppm F versus 1055 to 1100 ppm F in young children (primary teething), Issue 3 Proportion development new caries.

**5.1. Analysis**
Comparison 5 440 ppm F versus 1450 ppm F in early children (primary teeth), Outcome 1 dmft.

**5.2. Analysis**
Compare 5 440 ppm F versus 1450 ppm F in young children (firsthand dentition), Final result 2 Proportionality developing new caries.

**6.1. Depth psychology**
Comparison 6 0 ppm F versus 250 ppm F in children and adolescents (immature permanent teeth), Outcome 1 D(M)FS closest to 3 years.

**6.2. Psychoanalysis**
Comparison 6 0 ppm F versus 250 ppm F in children and adolescents (immature permanent dentition), Outcome 2 D(M)FT.

**6.3. Analysis**
Comparison 6 0 ppm F versus 250 ppm F in children and adolescents (immature permanent dentition), Outcome 3 Symmetry nonindustrial new caries.

**7.1. Analysis**
Comparison 7 0 ppm F versus 500 ppm F in children and adolescents (immature ineradicable dentition), Outcome 1 D(M)FS closest to 3 years.

**7.2. Analysis**
Comparison 7 0 ppm F versus 500 ppm F in children and adolescents (immature permanent dentition), Termination 2 D(M)FT.

**8.1. Psychoanalysis**
Comparison 8 0 ppm F versus 1000 ppm F in children and adolescents (immature permanent dentition), Outcome 1 D(M)FS.

**8.2. Analysis**
Compare 8 0 ppm F versus 1000 ppm F in children and adolescents (teenage permanent dentition), Outcome 2 D(M)FT.

**8.3. Analysis**
Comparison 8 0 ppm F versus 1000 ppm F in children and adolescents (immature permanent dentition), Effect 3 Proportion nonindustrial new caries.

**9.1. Analysis**
Comparison 9 0 ppm F versus 1450 ppm F in children and adolescents (embryonic permanent dentition), Outcome 1 D(M)FS.

**9.2. Psychoanalysis**
Comparison 9 0 ppm F versus 1450 ppm F in children and adolescents (immature everlasting dentition), Effect 2 D(M)FT.

**9.3. Analysis**
Comparison 9 0 ppm F versus 1450 ppm F in children and adolescents (immature permanent teething), Outcome 3 Proportion developing new tooth decay.

**10.1. Analysis**
Comparing 10 0 ppm F versus 2400 ppm F in children and adolescents (immature permanent dentition), Outcome 1 D(M)FS nighest to 3 years.

**10.2. Analysis**
Comparison 10 0 ppm F versus 2400 ppm F in children and adolescents (immature permanent dentition), Final result 2 D(M)FT.

**11.1. Analysis**
Comparison 11 250 ppm F versus 500 ppm F in children and adolescents (immature aeonian dentition), Outcome 1 D(M)FS.

**11.2. Analysis**
Comparison 11 250 ppm F versus 500 ppm F in children and adolescents (childly permanent odontiasis), Resultant 2 D(M)FT.

**12.1. Analysis**
Compare 12 250 ppm F versus 1000 ppm F in children and adolescents (immature permanent dentition), Issue 1 D(M)FS.

**12.2. Analysis**
Comparison 12 250 ppm F versus 1000 ppm F in children and adolescents (immature permanent dentition), Outcome 2 D(M)FT.

**12.3. Analysis**
Comparison 12 250 ppm F versus 1000 ppm F in children and adolescents (puerile permanent dentition), Outcome 3 Proportion developing new caries.

**13.1. Analysis**
Equivalence 13 500 ppm F versus 1000 ppm F in children and adolescents (immature permanent dentition), Outcome 1 D(M)FS.

**13.2. Analysis**
Equivalence 13 500 ppm F versus 1000 ppm F in children and adolescents (four-year-old permanent dentition), Outcome 2 D(M)FT.

**14.1. Psychoanalysis**
Comparability 14 1000 ppm F versus 1450 ppm F in children and adolescents (immature permanent dentition), Outcome 1 D(M)FS.

**14.2. Analysis**
Equivalence 14 1000 ppm F versus 1450 ppm F in children and adolescents (immature permanent dentition), Outcome 2 D(M)FT.

**14.3. Analysis**
Comparison 14 1000 ppm F versus 1450 ppm F in children and adolescents (immature permanent dentition), Outcome 3 Proportion developing new cavity.

**15.1. Analysis**
Equivalence 15 1000 ppm F versus 1700 ppm F in children and adolescents (immature irreversible odontiasis), Outcome 1 D(M)FS.

**15.2. Psychoanalysis**
Comparison 15 1000 ppm F versus 1700 ppm F in children and adolescents (immature unceasing dentition), Outcome 2 D(M)FT.

**16.1. Analysis**
Comparison 16 1000 ppm F versus 2400 ppm F in children and adolescents (prepubescent permanent dentition), Effect 1 D(M)FS.

**16.2. Analysis**
Comparing 16 1000 ppm F versus 2400 ppm F in children and adolescents (immature permanent dentition), Outcome 2 D(M)FT.

**17.1. Analysis**
Comparability 17 1450 ppm F versus 2400 ppm F in children and adolescents (immature permanent dentition), Outcome 1 D(M)FS.

**18.1. Analysis**
Comparison 18 1700 ppm F versus 2400 ppm F in children and adolescents (immature indissoluble dentition), Outcome 1 D(M)FS.

**18.2. Analysis**
Comparison 18 1700 ppm F versus 2400 ppm F in children and adolescents (immature stable dentition), Outcome 2 D(M)FT.

Update of

Fluoride toothpastes of different concentrations for preventing medical specialty dental caries in children and adolescents.

Walsh T, Worthington HV, Glenny AM, Appelbe P, Marinho VC, Shi X. Walsh T, et atomic number 13. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD007868. doi: 10.1002/14651858.CD007868.pub2. Cochrane Database Syst Rev. 2010. PMID: 20091655 Updated. Review.

Cited by 61 articles

Enamel Remineralization Competence of a Novel Fluoride-Incorporated Bioactive Methamphetamine Toothpaste-A Rise up Small-Hardness, Profilometric, and Micro-Computed Tomographic Psychoanalysis.

Farooq I, Ali S, Farooqi FA, AlHumaid J, Binhasan M, Shabib S, Vohra F, Abduljabbar T. Farooq I, et al. Imaging. 2021 Nov 9;7(4):752-766. doi: 10.3390/tomography7040063. Tomography. 2021. PMID: 34842827 Free PMC article.
The use of hydroxyapatite toothpaste to prevent dental caries.

O'Hagan-Wong K, Enax J, Meyer F, Ganss B. O'Hagan-Wong K, et al. Dentistry. 2021 Nov 22. Interior: 10.1007/s10266-021-00675-4. Online up of print. Odontology. 2021. PMID: 34807345 Review.
Relative Evaluation of Antibacterial Effect of Propolis and Aloe Vera, Xylitol, and Cpp-Acp Gels on Strep mutans and Lactobacillus in Vitro.

Hajiahmadi M, Faghri J, Salehi Z, Heidari F. Hajiahmadi M, et al. Int J Dent. 2021 November 8;2021:5842600. doi: 10.1155/2021/5842600. eCollection 2021. Int J Dent. 2021. PMID: 34790236 Free PMC article.
Concentration-Dependent Multi-Potentiality of L-Arginine: Antimicrobial Effect, Hydroxyapatite Stability, and MMPs Inhibition.

Bijle MN, Pichika MR, Mak KK, Parolia A, Babar MG, Yiu C, Daood U. Bijle MN, et Alabama. Molecules. 2021 Oct 31;26(21):6605. doi: 10.3390/molecules26216605. Molecules. 2021. PMID: 34771014 Self-governing PMC article.
Impact of Sociodemographic Factors on Dental Tooth decay in Children and Availing Fluoride Treatment: A Study Based on National Survey of Children's Health (NSCH) Information 2016-2019.

Sathiyakumar T, Vasireddy D, Mondal S. Sathiyakumar T, et al. Cureus. 2021 Sep 30;13(9):e18395. doi: 10.7759/cureus.18395. eCollection 2021 Sept. Cureus. 2021. PMID: 34729273 Free PMC article.

Publication types

Meshwork terms

Substances

LinkOut - more resources

Full Text Sources
- Europe PubMed Midway
- PubMed Central
- Wiley
Greco-Roman deity
- ClinicalTrials.gov
- MedlinePlus Health Entropy

four out of five dentists surveyed preferred crest toothpaste

Source: https://pubmed.ncbi.nlm.nih.gov/30829399/

Dorian Maywood